BSI PD ISO/TR 21624:2020
$167.15
Nanotechnologies. Considerations for in vitro studies of airborne nano‐objects and their aggregates and agglomerates (NOAA)
| Published By | Publication Date | Number of Pages |
| BSI | 2020 | 38 |
This document collates information regarding the systems available for exposure and assessment of nano-objects and their aggregates and agglomerates (NOAA) for in vitro air exposure studies. It provides an overview of the various exposure systems and in vitro cell systems used to perform in vitro studies that simulate an inhalation toxicology study design.
PDF Catalog
| PDF Pages | PDF Title |
|---|---|
| 2 | National foreword |
| 6 | Foreword |
| 7 | Introduction |
| 9 | 1 Scope 2 Normative references 3 Terms and definitions |
| 10 | 4 Abbreviated terms |
| 11 | 5 Considerations for in vitro systems for assessing inhalation exposure to NOAA 5.1 Background |
| 12 | 5.2 Modes of exposure 5.2.1 General |
| 13 | 5.2.2 Considerations for ALI exposure systems |
| 17 | 5.3 Considerations for characterizing NOAA tested in vitro studies of airborne nanomaterials |
| 18 | 5.4 Choice of cell systems 5.4.1 General 5.4.2 Mono-culture systems |
| 20 | 5.4.3 Co-cultures/three-dimensional systems |
| 22 | 6 Choice of appropriate dose and dose metrics 6.1 General |
| 23 | 6.2 In silico methods to assess dose/dose metrics and deposition |
| 24 | 7 Summary |
| 25 | Annex A (informative) Application of adverse outcome pathways (AOPs) to design in vitro-based approaches |
| 26 | Bibliography |
