ASTM-E1242:2008 Edition
$35.75
E1242-97(2008) Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis
Published By | Publication Date | Number of Pages |
ASTM | 2008 |
1.1 This practice covers a procedure for estimating the fathead minnow ( Pimephales promelas ) 96-h LC50 of nonreactive (that is, covalently bonded without unsaturated residues) and nonelectrolytic (that is, require vigorous reagents to facilitate substitution, addition, replacement reactions and are non-ionic, non-dissociating in aqueous solutions) organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship.
1.2 This procedure is accurate for organic chemicals that are toxic due to narcosis and are non-reactive and non-electrolytic. Examples of appropriate chemicals are: alcohols, ketones, ethers, simple halogenated aliphatics, aromatics, and aliphatic substituted aromatics. It is not appropriate for chemicals whose structures include a potential toxiphore (that structural component of a chemical molecule that has been identified to show mammalian toxicity, for example CN is known to be reponsible for inactivation of enzymes, NO 2 for decoupling of oxidative phosphorylation, both leading to mammalian toxicity). Examples of inappropriate chemicals are: carbamates, organophosphates, phenols, beta-gamma unsaturated alcohols, electrophiles, and quaternary ammonium salts.
PDF Catalog
PDF Pages | PDF Title |
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1 | Scope Referenced Documents Terminology Summary of Practice Significance and Use |
2 | Procedure Report |